Collapse after Trilostane (Vetoryl) in dogs

The FDA has received 218 reports of collapse in dogs after Trilostane. That is 1.8% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported unusually often with this medicine.

218Reports

72%Marked serious

20%Recovered

28%Died or euthanised

37 daysTypical onset

How soon it started

Same day

13 7.4%

1–2 days

11 6.3%

3–7 days

25 14%

1–4 weeks

29 17%

Over a month

97 55%

How the animals did

Recovered

44 20%

Still unwell when reported

22 10%

Died

23 11%

Euthanised

39 18%

Not known

90 41%

Problems reported at the same time

75 34%

66 30%

61 28%

60 28%

56 26%

51 23%

45 21%

42 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

112

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause collapse in dogs?: 218 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 37 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

Collapse after Insulin 81 reports · 1.1% of its reports
Collapse after Phenylpropanolamine (Proin) 65 reports · 1.6% of its reports
Collapse after Levothyroxine 44 reports · 1.5% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with collapse