Malaise after Phenylpropanolamine (Proin) in dogs

24 reports to the FDA describe malaise in dogs given Phenylpropanolamine. That is 0.6% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

24Reports

54%Marked serious

42%Recovered

29%Died or euthanised

1 daysTypical onset

How soon it started

Same day

2 15%

1–2 days

6 46%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

5 38%

How the animals did

Recovered

10 42%

Still unwell when reported

4 17%

Died

4 17%

Euthanised

3 13%

Not known

3 13%

Problems reported at the same time

13 54%

8 33%

8 33%

7 29%

6 25%

3 13%

3 13%

3 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause malaise in dogs?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Malaise with similar medicines

Malaise after Trilostane (Vetoryl) 283 reports · 2.4% of its reports
Malaise after Insulin 73 reports · 1.0% of its reports
Malaise after Levothyroxine 29 reports · 1.0% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with malaise