Malaise after Trilostane (Vetoryl) in dogs

283 reports to the FDA describe malaise in dogs given Trilostane. That is 2.4% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

283Reports

64%Marked serious

11%Recovered

23%Died or euthanised

52 daysTypical onset

How soon it started

Same day

8 3.6%

1–2 days

10 4.5%

3–7 days

20 9.0%

1–4 weeks

50 23%

Over a month

134 60%

How the animals did

Recovered

31 11%

Still unwell when reported

47 17%

Died

21 7.4%

Euthanised

43 15%

Not known

141 50%

Problems reported at the same time

137 48%

107 38%

80 28%

74 26%

69 24%

66 23%

66 23%

64 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

142

12+ years

109

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause malaise in dogs?: 283 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 52 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Malaise with similar medicines

Malaise after Insulin 73 reports · 1.0% of its reports
Malaise after Phenylpropanolamine (Proin) 24 reports · 0.6% of its reports
Malaise after Levothyroxine 29 reports · 1.0% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with malaise