Liver problems after Permethrin + Pyriproxyfen in dogs

32 reports to the FDA describe liver problems in dogs given Permethrin + Pyriproxyfen. That is 6.6% of all reports for this medicine, compared with 4.6% across reports for all dog medicines.

32Reports
66%Marked serious
13%Recovered
31%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
5 22%
1–2 days
2 8.7%
3–7 days
0 0.0%
1–4 weeks
3 13%
Over a month
13 57%

How the animals did

Recovered
4 13%
Still unwell when reported
11 34%
Died
3 9.4%
Euthanised
7 22%
Not known
7 22%

Problems reported at the same time

17 53%
10 31%
Kidney problems
7 22%
Blood problems
6 19%

Age of the animals

Under 1 year
1
1–3 years
9
4–7 years
7
8–11 years
11
12+ years
3

About this medicine

Type: medicine.

Questions owners ask

Can Permethrin + Pyriproxyfen cause liver problems in dogs?
32 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Permethrin + Pyriproxyfen in dogs · Medicines most reported with liver problems