Loss of appetite after Permethrin + Pyriproxyfen in dogs

The FDA has received 62 reports of loss of appetite in dogs after Permethrin + Pyriproxyfen. That is 13% of all reports for this medicine, compared with 8.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

62Reports
45%Marked serious
26%Recovered
24%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
7 18%
1–2 days
6 15%
3–7 days
3 7.7%
1–4 weeks
3 7.7%
Over a month
20 51%

How the animals did

Recovered
15 24%
Recovered with lasting effects
1 1.6%
Still unwell when reported
21 34%
Died
4 6.5%
Euthanised
11 18%
Not known
10 16%

Problems reported at the same time

33 53%
26 42%
16 26%
13 21%
Blood problems
12 19%
Fever
11 18%

Age of the animals

Under 1 year
4
1–3 years
17
4–7 years
17
8–11 years
16
12+ years
6

About this medicine

Type: medicine.

Questions owners ask

Can Permethrin + Pyriproxyfen cause loss of appetite in dogs?
62 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

All reported side effects of Permethrin + Pyriproxyfen in dogs · Medicines most reported with loss of appetite