Lethargy after Permethrin + Pyriproxyfen in dogs

98 reports to the FDA describe lethargy in dogs given Permethrin + Pyriproxyfen. That is 20% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported unusually often with this medicine.

98Reports
41%Marked serious
41%Recovered
8.2%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
19 27%
1–2 days
11 15%
3–7 days
7 9.9%
1–4 weeks
5 7.0%
Over a month
29 41%

How the animals did

Recovered
39 40%
Recovered with lasting effects
1 1.0%
Still unwell when reported
32 33%
Died
3 3.1%
Euthanised
5 5.1%
Not known
18 18%

Problems reported at the same time

41 42%
14 14%
13 13%
Fever
10 10%
Allergic reaction
9 9.2%

Age of the animals

Under 1 year
14
1–3 years
31
4–7 years
27
8–11 years
17
12+ years
5

About this medicine

Type: medicine.

Questions owners ask

Can Permethrin + Pyriproxyfen cause lethargy in dogs?
98 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Permethrin + Pyriproxyfen in dogs · Medicines most reported with lethargy