Behaviour change after Permethrin + Pyriproxyfen in dogs

26 reports to the FDA describe behaviour change in dogs given Permethrin + Pyriproxyfen. That is 5.3% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports
50%Marked serious
38%Recovered
7.7%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
3 16%
1–2 days
1 5.3%
3–7 days
3 16%
1–4 weeks
2 11%
Over a month
10 53%

How the animals did

Recovered
10 38%
Still unwell when reported
10 38%
Died
1 3.8%
Euthanised
1 3.8%
Not known
4 15%

Problems reported at the same time

12 46%
11 42%
9 35%
Collapse
5 19%
Inappropriate urination
4 15%
Vocalising
3 12%

Age of the animals

Under 1 year
2
1–3 years
11
4–7 years
6
8–11 years
6
12+ years
1

About this medicine

Type: medicine.

Questions owners ask

Can Permethrin + Pyriproxyfen cause behaviour change in dogs?
26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Permethrin + Pyriproxyfen in dogs · Medicines most reported with behaviour change