Liver problems after Keppra in dogs

The FDA has received 24 reports of liver problems in dogs after Keppra. That is 13% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

24Reports
96%Marked serious
0.0%Recovered
46%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
6 30%
1–2 days
3 15%
3–7 days
3 15%
1–4 weeks
2 10%
Over a month
6 30%

How the animals did

Still unwell when reported
12 50%
Died
4 17%
Euthanised
7 29%
Not known
1 4.2%

Problems reported at the same time

22 92%
11 46%
Diarrhea
7 29%
Wobbliness (ataxia)
6 25%
Weakness
6 25%
Didn't work as expected
6 25%
Vomiting
5 21%

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
1
8–11 years
11
12+ years
10

About this medicine

Type: medicine.

Questions owners ask

Can Keppra cause liver problems in dogs?
24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Keppra in dogs · Medicines most reported with liver problems