Excessive urination after Diphenhydramine in dogs

67 reports to the FDA describe excessive urination in dogs given Diphenhydramine. That is 1.4% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

67Reports
58%Marked serious
18%Recovered
16%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
25 45%
1–2 days
4 7.3%
3–7 days
4 7.3%
1–4 weeks
12 22%
Over a month
10 18%

How the animals did

Recovered
10 15%
Recovered with lasting effects
2 3.0%
Still unwell when reported
33 49%
Died
4 6.0%
Euthanised
7 10%
Not known
11 16%

Problems reported at the same time

Age of the animals

Under 1 year
5
1–3 years
22
4–7 years
5
8–11 years
21
12+ years
14

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause excessive urination in dogs?
67 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive urination with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with excessive urination