Excessive thirst after Diphenhydramine in dogs

The FDA has received 96 reports of excessive thirst in dogs after Diphenhydramine. That is 2.0% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

96Reports
61%Marked serious
17%Recovered
15%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
37 48%
1–2 days
7 9.1%
3–7 days
7 9.1%
1–4 weeks
13 17%
Over a month
13 17%

How the animals did

Recovered
13 14%
Recovered with lasting effects
3 3.1%
Still unwell when reported
48 50%
Died
7 7.3%
Euthanised
7 7.3%
Not known
18 19%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
24
4–7 years
17
8–11 years
31
12+ years
23

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause excessive thirst in dogs?
96 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive thirst with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with excessive thirst