Lethargy after Emodepside + Praziquantel (Profender) in cats

The FDA has received 909 reports of lethargy in cats after Emodepside + Praziquantel. That is 16% of all reports for this medicine, compared with 14% across reports for all cat medicines.

909Reports

61%Marked serious

32%Recovered

10%Died or euthanised

1 daysTypical onset

How soon it started

Same day

304 42%

1–2 days

266 37%

3–7 days

84 12%

1–4 weeks

45 6.2%

Over a month

24 3.3%

How the animals did

Recovered

293 32%

Recovered with lasting effects

2 0.2%

Still unwell when reported

75 8.3%

Died

48 5.3%

Euthanised

47 5.2%

Not known

444 49%

Problems reported at the same time

394 43%

223 25%

150 17%

128 14%

105 12%

98 11%

97 11%

92 10%

Age of the animals

Under 1 year

173

1–3 years

281

4–7 years

217

8–11 years

104

12+ years

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause lethargy in cats?: 909 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

Lethargy after Praziquantel 226 reports · 14% of its reports
Lethargy after Praziquantel + Pyrantel 213 reports · 17% of its reports
Lethargy after Pyrantel 159 reports · 28% of its reports
Lethargy after Fenbendazole 56 reports · 20% of its reports

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with lethargy