Drooling after Emodepside + Praziquantel (Profender) in cats

1,193 reports to the FDA describe drooling in cats given Emodepside + Praziquantel. That is 21% of all reports for this medicine, compared with 5.6% across reports for all cat medicines, so it is reported unusually often with this medicine.

1,193Reports

46%Marked serious

37%Recovered

2.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

798 91%

1–2 days

50 5.7%

3–7 days

15 1.7%

1–4 weeks

13 1.5%

Over a month

5 0.6%

How the animals did

Recovered

443 37%

Still unwell when reported

50 4.2%

Died

12 1.0%

Euthanised

14 1.2%

Not known

674 56%

Problems reported at the same time

Vomiting

161 13%

Application site reaction

133 11%

Lethargy

128 11%

Accidental exposure

116 9.7%

Loss of appetite

111 9.3%

Restlessness or agitation

103 8.6%

Tremors

96 8.0%

Wobbliness (ataxia)

88 7.4%

Age of the animals

Under 1 year

307

1–3 years

402

4–7 years

225

8–11 years

105

12+ years

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause drooling in cats?: 1,193 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

Drooling after Praziquantel 136 reports · 8.2% of its reports
Drooling after Praziquantel + Pyrantel 79 reports · 6.3% of its reports

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with drooling