Loss of appetite after Emodepside + Praziquantel (Profender) in cats

The FDA has received 665 reports of loss of appetite in cats after Emodepside + Praziquantel. That is 12% of all reports for this medicine, compared with 14% across reports for all cat medicines.

665Reports

63%Marked serious

29%Recovered

12%Died or euthanised

1 daysTypical onset

How soon it started

Same day

187 35%

1–2 days

205 39%

3–7 days

77 15%

1–4 weeks

44 8.3%

Over a month

15 2.8%

How the animals did

Recovered

189 28%

Recovered with lasting effects

3 0.5%

Still unwell when reported

62 9.3%

Died

38 5.7%

Euthanised

45 6.8%

Not known

328 49%

Problems reported at the same time

394 59%

197 30%

119 18%

111 17%

97 15%

88 13%

86 13%

84 13%

Age of the animals

Under 1 year

108

1–3 years

198

4–7 years

152

8–11 years

110

12+ years

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause loss of appetite in cats?: 665 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

Loss of appetite after Praziquantel 215 reports · 13% of its reports
Loss of appetite after Praziquantel + Pyrantel 144 reports · 11% of its reports
Loss of appetite after Pyrantel 125 reports · 22% of its reports
Loss of appetite after Fenbendazole 49 reports · 17% of its reports
Loss of appetite after Febantel + Praziquantel + Pyrantel (Drontal Plus) 22 reports · 31% of its reports

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with loss of appetite