Weight loss after Emodepside + Praziquantel (Profender) in cats

144 reports to the FDA describe weight loss in cats given Emodepside + Praziquantel. That is 2.5% of all reports for this medicine, compared with 4.6% across reports for all cat medicines, so it is reported less often than average with this medicine.

144Reports
75%Marked serious
17%Recovered
19%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
25 22%
1–2 days
33 29%
3–7 days
20 18%
1–4 weeks
20 18%
Over a month
14 13%

How the animals did

Recovered
24 17%
Still unwell when reported
19 13%
Died
11 7.6%
Euthanised
16 11%
Not known
74 51%

Problems reported at the same time

Loss of appetite
86 60%
Lethargy
69 48%
Vomiting
48 33%
Hair loss
29 20%
Diarrhea
28 19%
Liver problems
26 18%
Death
26 18%
Dehydration
23 16%

Age of the animals

Under 1 year
23
1–3 years
31
4–7 years
32
8–11 years
34
12+ years
24

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause weight loss in cats?
144 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weight loss with similar medicines

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with weight loss