Liver problems after Emodepside + Praziquantel (Profender) in cats

The FDA has received 89 reports of liver problems in cats after Emodepside + Praziquantel. That is 1.6% of all reports for this medicine, compared with 2.8% across reports for all cat medicines, so it is reported less often than average with this medicine.

89Reports

78%Marked serious

16%Recovered

35%Died or euthanised

1 daysTypical onset

How soon it started

Same day

22 32%

1–2 days

19 28%

3–7 days

13 19%

1–4 weeks

9 13%

Over a month

5 7.4%

How the animals did

Recovered

14 16%

Still unwell when reported

8 9.0%

Died

17 19%

Euthanised

14 16%

Not known

36 40%

Problems reported at the same time

54 61%

50 56%

31 35%

26 29%

26 29%

20 22%

15 17%

15 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause liver problems in cats?: 89 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Praziquantel + Pyrantel 26 reports · 2.1% of its reports

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with liver problems