Kidney problems after Emodepside + Praziquantel (Profender) in cats

88 reports to the FDA describe kidney problems in cats given Emodepside + Praziquantel. That is 1.5% of all reports for this medicine, compared with 4.5% across reports for all cat medicines, so it is reported less often than average with this medicine.

88Reports

84%Marked serious

14%Recovered

42%Died or euthanised

1 daysTypical onset

How soon it started

Same day

29 40%

1–2 days

21 29%

3–7 days

12 16%

1–4 weeks

8 11%

Over a month

3 4.1%

How the animals did

Recovered

12 14%

Still unwell when reported

12 14%

Died

15 17%

Euthanised

22 25%

Not known

27 31%

Problems reported at the same time

52 59%

48 55%

36 41%

23 26%

20 23%

20 23%

20 23%

17 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause kidney problems in cats?: 88 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Praziquantel + Pyrantel 21 reports · 1.7% of its reports
Kidney problems after Pyrantel 34 reports · 6.1% of its reports

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with kidney problems