Kidney problems after Praziquantel + Pyrantel in cats

The FDA has received 21 reports of kidney problems in cats after Praziquantel + Pyrantel. That is 1.7% of all reports for this medicine, compared with 4.5% across reports for all cat medicines, so it is reported less often than average with this medicine.

21Reports

62%Marked serious

0.0%Recovered

43%Died or euthanised

4 daysTypical onset

How soon it started

Same day

3 25%

1–2 days

2 17%

3–7 days

4 33%

1–4 weeks

3 25%

Over a month

0 0.0%

How the animals did

Still unwell when reported

2 9.5%

Died

6 29%

Euthanised

3 14%

Not known

10 48%

Problems reported at the same time

12 57%

11 52%

9 43%

8 38%

Abnormal radiograph finding

6 29%

Liver problems

5 24%

Vomiting

5 24%

Dehydration

4 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause kidney problems in cats?: 21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Emodepside + Praziquantel (Profender) 88 reports · 1.5% of its reports
Kidney problems after Pyrantel 34 reports · 6.1% of its reports

All reported side effects of Praziquantel + Pyrantel in cats · Medicines most reported with kidney problems