Wobbliness (ataxia) after Praziquantel + Pyrantel in cats

The FDA has received 453 reports of wobbliness (ataxia) in cats after Praziquantel + Pyrantel. That is 36% of all reports for this medicine, compared with 4.7% across reports for all cat medicines, so it is reported unusually often with this medicine.

453Reports
37%Marked serious
29%Recovered
4.9%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
190 79%
1–2 days
29 12%
3–7 days
10 4.1%
1–4 weeks
6 2.5%
Over a month
6 2.5%

How the animals did

Recovered
132 29%
Still unwell when reported
26 5.7%
Died
11 2.4%
Euthanised
11 2.4%
Not known
273 60%

Problems reported at the same time

Age of the animals

Under 1 year
57
1–3 years
91
4–7 years
106
8–11 years
82
12+ years
85

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause wobbliness (ataxia) in cats?
453 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

All reported side effects of Praziquantel + Pyrantel in cats · Medicines most reported with wobbliness (ataxia)