Behaviour change after Praziquantel + Pyrantel in cats

88 reports to the FDA describe behaviour change in cats given Praziquantel + Pyrantel. That is 7.0% of all reports for this medicine, compared with 5.4% across reports for all cat medicines.

88Reports

64%Marked serious

49%Recovered

6.8%Died or euthanised

Same dayTypical onset

How soon it started

Same day

44 60%

1–2 days

12 16%

3–7 days

6 8.2%

1–4 weeks

8 11%

Over a month

3 4.1%

How the animals did

Recovered

42 48%

Recovered with lasting effects

1 1.1%

Still unwell when reported

7 8.0%

Died

1 1.1%

Euthanised

5 5.7%

Not known

32 36%

Problems reported at the same time

29 33%

27 31%

23 26%

16 18%

15 17%

12 14%

8 9.1%

Restlessness or agitation

7 8.0%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause behaviour change in cats?: 88 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

Behaviour change after Emodepside + Praziquantel (Profender) 385 reports · 6.7% of its reports
Behaviour change after Praziquantel 159 reports · 9.6% of its reports
Behaviour change after Pyrantel 28 reports · 5.0% of its reports

All reported side effects of Praziquantel + Pyrantel in cats · Medicines most reported with behaviour change