Loss of appetite after Praziquantel + Pyrantel in cats

The FDA has received 144 reports of loss of appetite in cats after Praziquantel + Pyrantel. That is 11% of all reports for this medicine, compared with 14% across reports for all cat medicines.

144Reports
59%Marked serious
38%Recovered
14%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
37 34%
1–2 days
38 35%
3–7 days
10 9.3%
1–4 weeks
16 15%
Over a month
7 6.5%

How the animals did

Recovered
53 37%
Recovered with lasting effects
2 1.4%
Still unwell when reported
20 14%
Died
14 9.7%
Euthanised
6 4.2%
Not known
49 34%

Problems reported at the same time

Lethargy
66 46%
Vomiting
50 35%
Wobbliness (ataxia)
35 24%
Behaviour change
23 16%
Death
19 13%
Fever
18 13%
Adipsia
18 13%
Drooling
17 12%

Age of the animals

Under 1 year
40
1–3 years
37
4–7 years
22
8–11 years
22
12+ years
15

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause loss of appetite in cats?
144 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

All reported side effects of Praziquantel + Pyrantel in cats · Medicines most reported with loss of appetite