Lethargy after Praziquantel + Pyrantel in cats

The FDA has received 213 reports of lethargy in cats after Praziquantel + Pyrantel. That is 17% of all reports for this medicine, compared with 14% across reports for all cat medicines.

213Reports

45%Marked serious

32%Recovered

12%Died or euthanised

Same dayTypical onset

How soon it started

Same day

68 54%

1–2 days

32 25%

3–7 days

10 7.9%

1–4 weeks

8 6.3%

Over a month

8 6.3%

How the animals did

Recovered

67 31%

Recovered with lasting effects

2 0.9%

Still unwell when reported

21 9.9%

Died

18 8.5%

Euthanised

8 3.8%

Not known

97 46%

Problems reported at the same time

83 39%

66 31%

66 31%

29 14%

26 12%

23 11%

21 9.9%

21 9.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause lethargy in cats?: 213 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

Lethargy after Emodepside + Praziquantel (Profender) 909 reports · 16% of its reports
Lethargy after Praziquantel 226 reports · 14% of its reports
Lethargy after Pyrantel 159 reports · 28% of its reports
Lethargy after Fenbendazole 56 reports · 20% of its reports

All reported side effects of Praziquantel + Pyrantel in cats · Medicines most reported with lethargy