Behaviour change after Emodepside + Praziquantel (Profender) in cats

385 reports to the FDA describe behaviour change in cats given Emodepside + Praziquantel. That is 6.7% of all reports for this medicine, compared with 5.4% across reports for all cat medicines.

385Reports
56%Marked serious
42%Recovered
5.7%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
231 68%
1–2 days
59 17%
3–7 days
21 6.2%
1–4 weeks
21 6.2%
Over a month
7 2.1%

How the animals did

Recovered
159 41%
Recovered with lasting effects
1 0.3%
Still unwell when reported
35 9.1%
Died
8 2.1%
Euthanised
14 3.6%
Not known
168 44%

Problems reported at the same time

Age of the animals

Under 1 year
49
1–3 years
120
4–7 years
88
8–11 years
60
12+ years
33

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause behaviour change in cats?
385 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with behaviour change