Hair loss after Emodepside + Praziquantel (Profender) in cats

1,685 reports to the FDA describe hair loss in cats given Emodepside + Praziquantel. That is 29% of all reports for this medicine, compared with 14% across reports for all cat medicines, so it is reported unusually often with this medicine.

1,685Reports

51%Marked serious

21%Recovered

1.2%Died or euthanised

2 daysTypical onset

How soon it started

Same day

174 13%

1–2 days

601 46%

3–7 days

348 27%

1–4 weeks

148 11%

Over a month

35 2.7%

How the animals did

Recovered

348 21%

Recovered with lasting effects

3 0.2%

Still unwell when reported

118 7.0%

Died

13 0.8%

Euthanised

8 0.5%

Not known

1,195 71%

Problems reported at the same time

Application site reaction

578 34%

334 20%

308 18%

98 5.8%

69 4.1%

Skin rash or irritation

56 3.3%

Loss of appetite

55 3.3%

Behaviour change

48 2.8%

Age of the animals

Under 1 year

1–3 years

431

4–7 years

467

8–11 years

406

12+ years

207

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause hair loss in cats?: 1,685 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hair loss with similar medicines

Hair loss after Praziquantel 85 reports · 5.1% of its reports
Hair loss after Praziquantel + Pyrantel 44 reports · 3.5% of its reports

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with hair loss