Skin rash or irritation after Emodepside + Praziquantel (Profender) in cats

The FDA has received 99 reports of skin rash or irritation in cats after Emodepside + Praziquantel. That is 1.7% of all reports for this medicine, compared with 2.0% across reports for all cat medicines.

99Reports

62%Marked serious

25%Recovered

2.0%Died or euthanised

3 daysTypical onset

How soon it started

Same day

18 27%

1–2 days

12 18%

3–7 days

14 21%

1–4 weeks

18 27%

Over a month

5 7.5%

How the animals did

Recovered

25 25%

Still unwell when reported

9 9.1%

Euthanised

2 2.0%

Not known

63 64%

Problems reported at the same time

Hair loss

56 57%

Itching

44 44%

Application site reaction

30 30%

Skin redness

14 14%

Skin scab

10 10%

Skin irritation

9 9.1%

Lethargy

8 8.1%

Fever

7 7.1%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause skin rash or irritation in cats?: 99 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with skin rash or irritation