Application site reaction after Emodepside + Praziquantel (Profender) in cats

The FDA has received 945 reports of application site reaction in cats after Emodepside + Praziquantel. That is 16% of all reports for this medicine, compared with 8.1% across reports for all cat medicines, so it is reported unusually often with this medicine.

945Reports
45%Marked serious
29%Recovered
1.6%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
241 33%
1–2 days
240 33%
3–7 days
161 22%
1–4 weeks
72 9.8%
Over a month
17 2.3%

How the animals did

Recovered
272 29%
Recovered with lasting effects
2 0.2%
Still unwell when reported
102 11%
Died
7 0.7%
Euthanised
8 0.8%
Not known
554 59%

Problems reported at the same time

Age of the animals

Under 1 year
121
1–3 years
302
4–7 years
228
8–11 years
165
12+ years
77

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause application site reaction in cats?
945 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Application site reaction with similar medicines

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with application site reaction