Itching after Emodepside + Praziquantel (Profender) in cats

The FDA has received 615 reports of itching in cats after Emodepside + Praziquantel. That is 11% of all reports for this medicine, compared with 8.9% across reports for all cat medicines.

615Reports
56%Marked serious
28%Recovered
2.8%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
179 39%
1–2 days
145 31%
3–7 days
73 16%
1–4 weeks
45 9.8%
Over a month
19 4.1%

How the animals did

Recovered
168 27%
Recovered with lasting effects
2 0.3%
Still unwell when reported
53 8.6%
Died
10 1.6%
Euthanised
7 1.1%
Not known
375 61%

Problems reported at the same time

Hair loss
334 54%
Application site reaction
219 36%
Skin redness
95 15%
Behaviour change
63 10%
Lethargy
62 10%
Drooling
56 9.1%
Loss of appetite
48 7.8%
Vomiting
47 7.6%

Age of the animals

Under 1 year
94
1–3 years
187
4–7 years
143
8–11 years
101
12+ years
61

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause itching in cats?
615 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Itching with similar medicines

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with itching