Weakness after Praziquantel + Pyrantel in cats

The FDA has received 32 reports of weakness in cats after Praziquantel + Pyrantel. That is 2.5% of all reports for this medicine, compared with 1.2% across reports for all cat medicines, so it is reported unusually often with this medicine.

32Reports

41%Marked serious

25%Recovered

19%Died or euthanised

Same dayTypical onset

How soon it started

Same day

14 70%

1–2 days

1 5.0%

3–7 days

2 10%

1–4 weeks

2 10%

Over a month

1 5.0%

How the animals did

Recovered

8 25%

Still unwell when reported

4 13%

Died

2 6.3%

Euthanised

4 13%

Not known

14 44%

Problems reported at the same time

22 69%

8 25%

6 19%

5 16%

5 16%

4 13%

3 9.4%

3 9.4%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause weakness in cats?: 32 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weakness with similar medicines

Weakness after Emodepside + Praziquantel (Profender) 80 reports · 1.4% of its reports

All reported side effects of Praziquantel + Pyrantel in cats · Medicines most reported with weakness