Dehydration after Praziquantel + Pyrantel in cats

The FDA has received 28 reports of dehydration in cats after Praziquantel + Pyrantel. That is 2.2% of all reports for this medicine, compared with 2.0% across reports for all cat medicines.

28Reports

46%Marked serious

21%Recovered

29%Died or euthanised

1 daysTypical onset

How soon it started

Same day

5 42%

1–2 days

2 17%

3–7 days

1 8.3%

1–4 weeks

3 25%

Over a month

1 8.3%

How the animals did

Recovered

6 21%

Died

4 14%

Euthanised

4 14%

Not known

14 50%

Problems reported at the same time

17 61%

13 46%

13 46%

8 29%

6 21%

6 21%

5 18%

4 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause dehydration in cats?: 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Dehydration with similar medicines

Dehydration after Emodepside + Praziquantel (Profender) 87 reports · 1.5% of its reports
Dehydration after Pyrantel 27 reports · 4.8% of its reports

All reported side effects of Praziquantel + Pyrantel in cats · Medicines most reported with dehydration