Liver problems after Praziquantel + Pyrantel in cats

The FDA has received 26 reports of liver problems in cats after Praziquantel + Pyrantel. That is 2.1% of all reports for this medicine, compared with 2.8% across reports for all cat medicines.

26Reports

58%Marked serious

23%Recovered

38%Died or euthanised

2 daysTypical onset

How soon it started

Same day

5 36%

1–2 days

3 21%

3–7 days

4 29%

1–4 weeks

2 14%

Over a month

0 0.0%

How the animals did

Recovered

6 23%

Died

6 23%

Euthanised

4 15%

Not known

10 38%

Problems reported at the same time

12 46%

10 38%

9 35%

8 31%

6 23%

6 23%

5 19%

5 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause liver problems in cats?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Emodepside + Praziquantel (Profender) 89 reports · 1.6% of its reports

All reported side effects of Praziquantel + Pyrantel in cats · Medicines most reported with liver problems