Adipsia after Emodepside + Praziquantel (Profender) in cats

The FDA has received 104 reports of adipsia in cats after Emodepside + Praziquantel. That is 1.8% of all reports for this medicine, compared with 0.9% across reports for all cat medicines, so it is reported unusually often with this medicine.

104Reports

66%Marked serious

31%Recovered

14%Died or euthanised

1 daysTypical onset

How soon it started

Same day

31 39%

1–2 days

24 30%

3–7 days

17 22%

1–4 weeks

5 6.3%

Over a month

2 2.5%

How the animals did

Recovered

32 31%

Still unwell when reported

5 4.8%

Died

6 5.8%

Euthanised

9 8.7%

Not known

52 50%

Problems reported at the same time

97 93%

67 64%

29 28%

21 20%

20 19%

19 18%

18 17%

16 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause adipsia in cats?: 104 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Adipsia with similar medicines

Adipsia after Praziquantel 25 reports · 1.5% of its reports

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with adipsia