Liver problems after Ursodiol in dogs

226 reports to the FDA describe liver problems in dogs given Ursodiol. That is 31% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

226Reports
69%Marked serious
6.2%Recovered
26%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
14 7.9%
1–2 days
11 6.2%
3–7 days
11 6.2%
1–4 weeks
50 28%
Over a month
91 51%

How the animals did

Recovered
11 4.9%
Recovered with lasting effects
3 1.3%
Still unwell when reported
79 35%
Died
15 6.6%
Euthanised
43 19%
Not known
75 33%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
12
4–7 years
25
8–11 years
115
12+ years
73

About this medicine

Type: medicine.

Questions owners ask

Can Ursodiol cause liver problems in dogs?
226 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Ursodiol in dogs · Medicines most reported with liver problems