Lethargy after Ursodiol in dogs

165 reports to the FDA describe lethargy in dogs given Ursodiol. That is 23% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported unusually often with this medicine.

165Reports
71%Marked serious
18%Recovered
25%Died or euthanised
22 daysTypical onset
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How soon it started

Same day
19 14%
1–2 days
12 9.1%
3–7 days
7 5.3%
1–4 weeks
40 30%
Over a month
54 41%

How the animals did

Recovered
27 16%
Recovered with lasting effects
2 1.2%
Still unwell when reported
59 36%
Died
11 6.7%
Euthanised
31 19%
Not known
35 21%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
10
4–7 years
16
8–11 years
70
12+ years
68

About this medicine

Type: medicine.

Questions owners ask

Can Ursodiol cause lethargy in dogs?
165 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 22 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Ursodiol in dogs · Medicines most reported with lethargy