Polyphagia after Trilostane (Vetoryl) in dogs

228 reports to the FDA describe polyphagia in dogs given Trilostane. That is 1.9% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

228Reports

48%Marked serious

12%Recovered

7.5%Died or euthanised

51 daysTypical onset

How soon it started

Same day

10 6.1%

1–2 days

2 1.2%

3–7 days

7 4.2%

1–4 weeks

41 25%

Over a month

105 64%

How the animals did

Recovered

24 11%

Recovered with lasting effects

3 1.3%

Still unwell when reported

30 13%

Died

2 0.9%

Euthanised

15 6.6%

Not known

154 68%

Problems reported at the same time

Excessive thirst

92 40%

Excessive urination

76 33%

Liver problems

75 33%

Didn't work as expected

54 24%

45 20%

38 17%

36 16%

32 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

117

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause polyphagia in dogs?: 228 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 51 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Polyphagia with similar medicines

Polyphagia after Insulin 37 reports · 0.5% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with polyphagia