Musculoskeletal disorder after Trilostane (Vetoryl) in dogs

The FDA has received 55 reports of musculoskeletal disorder in dogs after Trilostane. That is 0.5% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

55Reports

64%Marked serious

11%Recovered

16%Died or euthanised

56 daysTypical onset

How soon it started

Same day

2 4.7%

1–2 days

3 7.0%

3–7 days

2 4.7%

1–4 weeks

11 26%

Over a month

25 58%

How the animals did

Recovered

6 11%

Still unwell when reported

8 15%

Died

1 1.8%

Euthanised

8 15%

Not known

32 58%

Problems reported at the same time

18 33%

13 24%

13 24%

13 24%

9 16%

9 16%

8 15%

7 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause musculoskeletal disorder in dogs?: 55 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 56 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Musculoskeletal disorder with similar medicines

Musculoskeletal disorder after Insulin 22 reports · 0.3% of its reports
Musculoskeletal disorder after Phenylpropanolamine (Proin) 20 reports · 0.5% of its reports
Musculoskeletal disorder after Levothyroxine 30 reports · 1.0% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with musculoskeletal disorder