Weight loss after Pyrantel + Sarolaner (Simparica Trio) in dogs

317 reports to the FDA describe weight loss in dogs given Pyrantel + Sarolaner. That is 0.6% of all reports for this medicine, compared with 1.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

317Reports
71%Marked serious
9.8%Recovered
15%Died or euthanised
2 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
84 29%
1–2 days
71 24%
3–7 days
30 10%
1–4 weeks
43 15%
Over a month
66 22%

How the animals did

Recovered
30 9.5%
Recovered with lasting effects
1 0.3%
Still unwell when reported
183 58%
Died
19 6.0%
Euthanised
27 8.5%
Not known
57 18%

Problems reported at the same time

130 41%
110 35%
107 34%
46 15%
36 11%
36 11%

Age of the animals

Under 1 year
35
1–3 years
79
4–7 years
79
8–11 years
77
12+ years
39

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause weight loss in dogs?
317 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weight loss with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with weight loss