Unable to stand after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 150 reports of unable to stand in dogs after Pyrantel + Sarolaner. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

150Reports

77%Marked serious

29%Recovered

15%Died or euthanised

1 daysTypical onset

How soon it started

Same day

66 47%

1–2 days

32 23%

3–7 days

10 7.1%

1–4 weeks

18 13%

Over a month

14 10%

How the animals did

Recovered

43 29%

Still unwell when reported

56 37%

Died

10 6.7%

Euthanised

12 8.0%

Not known

29 19%

Problems reported at the same time

51 34%

43 29%

42 28%

41 27%

33 22%

22 15%

21 14%

18 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause unable to stand in dogs?: 150 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unable to stand with similar medicines

Unable to stand after Pyrantel 20 reports · 0.4% of its reports
Unable to stand after Praziquantel + Pyrantel 29 reports · 0.8% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with unable to stand