Unable to stand after Praziquantel + Pyrantel in dogs

The FDA has received 29 reports of unable to stand in dogs after Praziquantel + Pyrantel. That is 0.8% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

29Reports

90%Marked serious

28%Recovered

17%Died or euthanised

Same dayTypical onset

How soon it started

Same day

19 68%

1–2 days

7 25%

3–7 days

1 3.6%

1–4 weeks

1 3.6%

Over a month

0 0.0%

How the animals did

Recovered

8 28%

Still unwell when reported

2 6.9%

Died

5 17%

Not known

14 48%

Problems reported at the same time

9 31%

9 31%

8 28%

7 24%

5 17%

5 17%

5 17%

4 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause unable to stand in dogs?: 29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unable to stand with similar medicines

Unable to stand after Pyrantel + Sarolaner (Simparica Trio) 150 reports · 0.3% of its reports
Unable to stand after Pyrantel 20 reports · 0.4% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with unable to stand