Reluctant to move after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 118 reports of reluctant to move in dogs after Pyrantel + Sarolaner. That is 0.2% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

118Reports
63%Marked serious
31%Recovered
7.6%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
49 43%
1–2 days
29 25%
3–7 days
12 10%
1–4 weeks
15 13%
Over a month
10 8.7%

How the animals did

Recovered
36 31%
Still unwell when reported
43 36%
Died
5 4.2%
Euthanised
4 3.4%
Not known
30 25%

Problems reported at the same time

Age of the animals

Under 1 year
20
1–3 years
23
4–7 years
24
8–11 years
36
12+ years
11

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause reluctant to move in dogs?
118 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Reluctant to move with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with reluctant to move