Lameness after Pyrantel + Sarolaner (Simparica Trio) in dogs

147 reports to the FDA describe lameness in dogs given Pyrantel + Sarolaner. That is 0.3% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

147Reports
70%Marked serious
13%Recovered
8.8%Died or euthanised
3 daysTypical onset
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How soon it started

Same day
34 27%
1–2 days
29 23%
3–7 days
16 13%
1–4 weeks
11 8.7%
Over a month
37 29%

How the animals did

Recovered
19 13%
Still unwell when reported
85 58%
Died
2 1.4%
Euthanised
11 7.5%
Not known
30 20%

Problems reported at the same time

Age of the animals

Under 1 year
31
1–3 years
35
4–7 years
45
8–11 years
22
12+ years
13

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause lameness in dogs?
147 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lameness with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with lameness