Cough after Pyrantel + Sarolaner (Simparica Trio) in dogs

179 reports to the FDA describe cough in dogs given Pyrantel + Sarolaner. That is 0.3% of all reports for this medicine, compared with 0.8% across reports for all dog medicines, so it is reported less often than average with this medicine.

179Reports
56%Marked serious
22%Recovered
9.5%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
69 43%
1–2 days
25 15%
3–7 days
16 9.9%
1–4 weeks
20 12%
Over a month
32 20%

How the animals did

Recovered
40 22%
Still unwell when reported
73 41%
Died
10 5.6%
Euthanised
7 3.9%
Not known
49 27%

Problems reported at the same time

Age of the animals

Under 1 year
21
1–3 years
40
4–7 years
31
8–11 years
52
12+ years
29

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause cough in dogs?
179 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Cough with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with cough