Gagging after Pyrantel + Sarolaner (Simparica Trio) in dogs

88 reports to the FDA describe gagging in dogs given Pyrantel + Sarolaner. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

88Reports

43%Marked serious

34%Recovered

4.5%Died or euthanised

Same dayTypical onset

How soon it started

Same day

52 61%

1–2 days

20 24%

3–7 days

5 5.9%

1–4 weeks

4 4.7%

Over a month

4 4.7%

How the animals did

Recovered

30 34%

Still unwell when reported

28 32%

Died

3 3.4%

Euthanised

1 1.1%

Not known

26 30%

Problems reported at the same time

48 55%

26 30%

23 26%

20 23%

16 18%

12 14%

11 13%

9 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause gagging in dogs?: 88 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Gagging with similar medicines

Gagging after Fenbendazole 26 reports · 0.4% of its reports
Gagging after Pyrantel 73 reports · 1.5% of its reports
Gagging after Praziquantel + Pyrantel 22 reports · 0.6% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with gagging