Collapse after Pyrantel + Sarolaner (Simparica Trio) in dogs

224 reports to the FDA describe collapse in dogs given Pyrantel + Sarolaner. That is 0.4% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported less often than average with this medicine.

224Reports

96%Marked serious

29%Recovered

21%Died or euthanised

1 daysTypical onset

How soon it started

Same day

91 44%

1–2 days

35 17%

3–7 days

20 9.7%

1–4 weeks

39 19%

Over a month

21 10%

How the animals did

Recovered

64 29%

Still unwell when reported

85 38%

Died

28 13%

Euthanised

20 8.9%

Not known

27 12%

Problems reported at the same time

75 33%

74 33%

47 21%

46 21%

46 21%

41 18%

34 15%

30 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause collapse in dogs?: 224 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

Collapse after Fenbendazole 37 reports · 0.6% of its reports
Collapse after Pyrantel 88 reports · 1.8% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with collapse