Collapse after Pyrantel in dogs

The FDA has received 88 reports of collapse in dogs after Pyrantel. That is 1.8% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported unusually often with this medicine.

88Reports

68%Marked serious

25%Recovered

27%Died or euthanised

Same dayTypical onset

How soon it started

Same day

46 73%

1–2 days

4 6.3%

3–7 days

5 7.9%

1–4 weeks

4 6.3%

Over a month

4 6.3%

How the animals did

Recovered

22 25%

Still unwell when reported

21 24%

Died

18 20%

Euthanised

6 6.8%

Not known

21 24%

Problems reported at the same time

53 60%

49 56%

30 34%

24 27%

23 26%

21 24%

16 18%

11 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Pyrantel cause collapse in dogs?: 88 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

Collapse after Pyrantel + Sarolaner (Simparica Trio) 224 reports · 0.4% of its reports
Collapse after Fenbendazole 37 reports · 0.6% of its reports

All reported side effects of Pyrantel in dogs · Medicines most reported with collapse