Abnormal radiograph finding after Pyrantel + Sarolaner (Simparica Trio) in dogs

118 reports to the FDA describe abnormal radiograph finding in dogs given Pyrantel + Sarolaner. That is 0.2% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported less often than average with this medicine.

118Reports
87%Marked serious
9.3%Recovered
27%Died or euthanised
3 daysTypical onset
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How soon it started

Same day
31 28%
1–2 days
24 22%
3–7 days
15 14%
1–4 weeks
14 13%
Over a month
26 24%

How the animals did

Recovered
11 9.3%
Still unwell when reported
64 54%
Died
14 12%
Euthanised
18 15%
Not known
11 9.3%

Problems reported at the same time

Age of the animals

Under 1 year
26
1–3 years
33
4–7 years
24
8–11 years
26
12+ years
9

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause abnormal radiograph finding in dogs?
118 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal radiograph finding with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with abnormal radiograph finding