Swelling after Prednisolone + Trimeprazine in dogs

The FDA has received 81 reports of swelling in dogs after Prednisolone + Trimeprazine. That is 3.9% of all reports for this medicine, compared with 2.8% across reports for all dog medicines.

81Reports
36%Marked serious
20%Recovered
22%Died or euthanised
9 daysTypical onset
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How soon it started

Same day
15 27%
1–2 days
6 11%
3–7 days
4 7.3%
1–4 weeks
16 29%
Over a month
14 25%

How the animals did

Recovered
15 19%
Recovered with lasting effects
1 1.2%
Still unwell when reported
25 31%
Died
11 14%
Euthanised
7 8.6%
Not known
22 27%

Problems reported at the same time

Age of the animals

Under 1 year
8
1–3 years
18
4–7 years
26
8–11 years
15
12+ years
13

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause swelling in dogs?
81 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 9 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with swelling