Underdose after Praziquantel + Pyrantel in dogs

The FDA has received 65 reports of underdose in dogs after Praziquantel + Pyrantel. That is 1.8% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

65Reports

31%Marked serious

29%Recovered

7.7%Died or euthanised

Same dayTypical onset

How soon it started

Same day

28 61%

1–2 days

12 26%

3–7 days

4 8.7%

1–4 weeks

2 4.3%

Over a month

0 0.0%

How the animals did

Recovered

19 29%

Died

5 7.7%

Not known

41 63%

Problems reported at the same time

Vomiting

28 43%

Lethargy

17 26%

Diarrhea

14 22%

Incorrect dose administered

9 14%

8 12%

8 12%

5 7.7%

5 7.7%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause underdose in dogs?: 65 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Underdose with similar medicines

Underdose after Pyrantel + Sarolaner (Simparica Trio) 216 reports · 0.4% of its reports
Underdose after Febantel + Praziquantel + Pyrantel (Drontal Plus) 247 reports · 3.7% of its reports
Underdose after Fenbendazole 229 reports · 3.9% of its reports
Underdose after Pyrantel 82 reports · 1.7% of its reports
Underdose after Praziquantel 28 reports · 2.5% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with underdose