Elevated symmetrical dimethylarginine (sdma) after Polysulfated Glycosaminoglycan in dogs

The FDA has received 29 reports of elevated symmetrical dimethylarginine (sdma) in dogs after Polysulfated Glycosaminoglycan. That is 0.5% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

29Reports
62%Marked serious
14%Recovered
17%Died or euthanised
43 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
2 9.5%
1–2 days
0 0.0%
3–7 days
2 9.5%
1–4 weeks
6 29%
Over a month
11 52%

How the animals did

Recovered
4 14%
Still unwell when reported
9 31%
Died
1 3.4%
Euthanised
4 14%
Not known
11 38%

Problems reported at the same time

Kidney problems
19 66%
Liver problems
10 34%
Excessive urination
8 28%
Loss of appetite
8 28%
Excessive thirst
6 21%
Hyperphosphataemia
6 21%
Lethargy
5 17%
Decreased urine concentration
5 17%

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
2
8–11 years
10
12+ years
16

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause elevated symmetrical dimethylarginine (sdma) in dogs?
29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 43 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated symmetrical dimethylarginine (sdma) with similar medicines

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with elevated symmetrical dimethylarginine (sdma)