Elevated symmetrical dimethylarginine (sdma) after Estriol in dogs

23 reports to the FDA describe elevated symmetrical dimethylarginine (sdma) in dogs given Estriol. That is 1.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

23Reports
74%Marked serious
4.3%Recovered
13%Died or euthanised
230 daysTypical onset
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How soon it started

Same day
2 10%
1–2 days
1 5.0%
3–7 days
1 5.0%
1–4 weeks
1 5.0%
Over a month
15 75%

How the animals did

Recovered with lasting effects
1 4.3%
Still unwell when reported
17 74%
Euthanised
3 13%
Not known
2 8.7%

Problems reported at the same time

7 30%
Hypoalbuminaemia
6 26%

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
5
8–11 years
5
12+ years
11

About this medicine

Type: medicine.

Questions owners ask

Can Estriol cause elevated symmetrical dimethylarginine (sdma) in dogs?
23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 230 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated symmetrical dimethylarginine (sdma) with similar medicines

All reported side effects of Estriol in dogs · Medicines most reported with elevated symmetrical dimethylarginine (sdma)