Unable to stand after Phenylpropanolamine (Proin) in dogs

32 reports to the FDA describe unable to stand in dogs given Phenylpropanolamine. That is 0.8% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

32Reports
75%Marked serious
25%Recovered
44%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
10 43%
1–2 days
5 22%
3–7 days
1 4.3%
1–4 weeks
3 13%
Over a month
4 17%

How the animals did

Recovered
8 25%
Still unwell when reported
6 19%
Died
2 6.3%
Euthanised
12 38%
Not known
4 13%

Problems reported at the same time

Death
14 44%
Lethargy
12 38%
Vomiting
10 31%
Restlessness or agitation
9 28%
Wobbliness (ataxia)
8 25%
Weakness
8 25%
Loss of appetite
8 25%
Seizures
8 25%

Age of the animals

Under 1 year
0
1–3 years
3
4–7 years
4
8–11 years
10
12+ years
14

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause unable to stand in dogs?
32 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unable to stand with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with unable to stand