Reddening of the skin after Phenylpropanolamine (Proin) in dogs

The FDA has received 54 reports of reddening of the skin in dogs after Phenylpropanolamine. That is 1.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

54Reports
54%Marked serious
59%Recovered
1.9%Died or euthanised
Same dayTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
31 72%
1–2 days
5 12%
3–7 days
1 2.3%
1–4 weeks
1 2.3%
Over a month
5 12%

How the animals did

Recovered
31 57%
Recovered with lasting effects
1 1.9%
Still unwell when reported
6 11%
Euthanised
1 1.9%
Not known
15 28%

Problems reported at the same time

Vomiting
19 35%
Lethargy
10 19%
Breathing problems
8 15%
Restlessness or agitation
8 15%
Allergic reaction
7 13%
Diarrhea
6 11%
Behaviour change
5 9.3%
Overdose
5 9.3%

Age of the animals

Under 1 year
3
1–3 years
15
4–7 years
20
8–11 years
10
12+ years
4

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause reddening of the skin in dogs?
54 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Reddening of the skin with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with reddening of the skin